Diabetic foot is one of the most serious chronic complications in diabetic patients, mainly related to diabetic peripheral neuropathy, vasculopathy and trauma and infection. Its diagnosis and treatment should be carried out under the guidance of a doctor, and should not be used blindly, it is recommended to go to the hospital in time. At present, the treatment of diabetic foot mainly includes: general treatment, drug treatment and surgery. 1. General treatment: it includes controlling blood sugar and nutritional support. Under the guidance of doctors, individualized nutritional support programs should be formulated through blood glucose monitoring, nutritional screening and evaluation to maintain the stability of blood glucose. 2. Medication: Due to individual differences, there is no fastest, best and most effective medication, and suitable medication should be chosen according to one’s own situation. Commonly used drugs include: (1) Neurotrophic drugs, such as methylcobalamin, Epalrestat, lipoic acid, etc. 2) Antiplatelet therapy, which can effectively reduce the occurrence of cardiovascular disease, such as aspirin, clopidogrel and so on. 3) Combined with atrial fibrillation, anticoagulant drugs can be combined, such as heparin, warfarin, rivaroxaban. 4) Pain treatment: pain is one of the main symptoms of diabetic foot, commonly used pain medications include celecoxib, pregabalin, tramadol and so on. (5) Anti-infection treatment: when diabetic foot is combined with infection and gangrene, antibiotics should be applied systemically to avoid the spread of infection, and the specific drugs should be chosen according to the microbial culture results as appropriate. 3. Surgical treatment: mainly including interventional therapy, debridement, amputation and other treatment modes. In conclusion, diabetic foot should be based on their own situation, under the guidance of doctors to develop treatment programs, not blindly use drugs, delay the condition.