Chronic prostatitis is a common and frequent disease, and is most often seen in young adults, who are sexually active. As the number of patients with sexually transmitted urethritis increases, the incidence of trichomonas, fungal, gonococcal and non-gonococcal prostatitis is also on the rise and gaining attention. The reason for this is that there are many factors that are associated with the lack of timely and effective diagnosis and treatment of patients with sexually transmitted urethritis, inappropriate choice of antibiotics, and insufficient course of treatment. Direct infection from sexual intercourse is its main mode of transmission, and other means of transmission include episodic urethral infection, reflux of infected urine causing infection of the prostate, etc. The actual diagnosis: Because the symptoms of prostatitis are easily masked by the symptoms of urethritis, patients with sexually transmitted urethritis have acute urethritis symptoms remitted after a period of effective treatment, while still having obvious clinical symptoms such as discomfort in urination, pain and burning in the urethra, and painful lower abdominal perineal cramps. At this point, one should be highly suspicious of prostatitis after combined sexually transmitted urethritis and need to undergo routine examination of prostate fluid and pathogen testing. The pathogen testing is important for the diagnosis and treatment of chronic prostatitis, especially after sexually transmitted urethritis, and should pay attention to mixed infections and drug-resistant strains of infection. The results show that the causative agents of post-sexual urethritis prostatitis are mainly gonococcus, Chlamydia trachomatis and Mycoplasma solium. Treatment: For patients with clear pathogenic infections, intensive treatment with targeted antibiotics can be used based on drug sensitivity testing. Some scholars have reported medication duration of 1 to 4 months, or even up to 6 months, with a cure rate of 30% to 50%. However, due to the deepening understanding of the pathogenesis of chronic prostatitis, a wide range of comprehensive therapeutic measures can be carried out based on the use of antibiotic therapy, such as antispasmodic local tissue muscles, reducing uric acid, improving local and systemic immunity, improving the living regime and abstaining from bad habits, as well as the use of Chinese medicine, most of which can achieve satisfactory results.