Diabetic patients with blood glucose 25mmol / L either fasting blood glucose or 2 hours after meals blood glucose, are more than the normal range, you should seek medical attention in a timely manner, improve blood glucose, urine sugar, urine ketones, as well as blood gas analysis and other related examinations, to clarify whether the combination of diabetic ketoacidosis and other acute complications of diabetes mellitus, may need to use insulin therapy to reduce blood glucose. Clinically, the possibility of diabetic ketoacidosis should be considered in patients with unexplained nausea and vomiting, acidosis, water loss, shock, and coma, especially those with ketone odor of breath (rotten apple odor), low blood pressure and high urine output, regardless of whether there is a history of diabetes. Diabetic ketoacidosis can be diagnosed if blood glucose >11 mmol/L with ketonuria and ketonemia, blood pH <7.3 and/or blood bicarbonate <15 mmol/L. Patients with diabetic ketoacidosis should be rehydrated as soon as possible to restore blood volume, correct water loss, lower blood glucose, correct electrolyte and acid-base balance imbalance, and at the same time, actively search for and eliminate the triggers to prevent and treat complications, and to reduce the morbidity and mortality rate. When diabetic patients find high blood glucose level, they should consult a doctor in time and follow the doctor's instructions to standardize the treatment.