1, centripetal obesity, cortisolism is mostly mild to moderate obesity, rarely heavy obesity. Some facial and trunk obesity, but weight in the normal range. Typical centripetal obesity includes full moon face, buffalo back, hanging abdomen and supraclavicular fossa fat pad. A minority of cortisolism manifests as homogeneous obesity. Centripetal obesity is due to cortisol excess caused by abnormal fat metabolism and abnormal fat distribution. 2, hypertension and hypokalemia, cortisol has obvious sodium retention and potassium excretion effect. Total sodium and blood volume in the patient’s body expand, blood pressure rises and there may be mild edema. Urinary potassium excretion increases, and there may be hypokalemia and hyperkalemia, and even mild alkalosis. This type of hypertension is usually mild to moderate, and hypokalemia is also mild and rarely below 3.0 mmol/L. Sodium is usually normal. 3, negative nitrogen balance caused by clinical manifestations, cortisol patients protein anabolism decreased, catabolism accelerated, the body is in long-term negative nitrogen balance, the consequences of a series of clinical manifestations: thin skin, wide purple lines, capillary fragility increased susceptibility to petechiae; muscle atrophy and weakness; severe osteoporosis leading to pathological fractures, fractures in the ribs and thoracolumbar vertebrae; wound healing is not easy. 4, diabetes or reduced glucose tolerance, half of the patients have glucose tolerance injury, about 20% have overt diabetes. 5, growth disorders, adolescents and children with cortisol disease, will lead to growth stagnation, delayed puberty. Cortisol also has an inhibitory effect on the gonads. 6, gonadal dysfunction, most female patients have menstrual disorders and secondary amenorrhea, rarely ovulation; male manifestation of impotence or low sexual function. In addition to adrenocortical adenoma, other causes of cortisolism exist in varying degrees of increased secretion of adrenal androgens, which manifests as acne, hirsutism, and heavy manifestations of female masculinization. 7, mental symptoms, most patients have varying degrees of mental abnormalities. Most are mild, such as insomnia, inability to concentrate, memory loss, moderate with euphoria, melancholy, crying or mania, a few severe cases resemble melancholia or schizophrenia. 8, other clinical manifestations: decreased body resistance, easy to infect skin folliculitis, periodontitis, urinary tract infection, nail fungus and skin ringworm. The incidence of kidney stones is about 15%.