Papules in AIDS patients mainly appear as solid-like protrusions on the skin and mucous membranes, which can fade when pressed and are as large as a bean, with red-like rash changes, often mixed with pemphigus, herpes, and maculopapular rash, above the skin. It appears after a period of fever, often with pruritus, and gradually subsides as the body temperature drops, or returns to normal earlier than the body temperature drops. The rash is not specific, so papules cannot be used as a basis for the diagnosis of AIDS. The papules of AIDS are mainly due to a major disruption of immunity and the development of skin and mucosal lesions, most of which are caused by skin infections. Patients with AIDS also often develop herpes zoster, which is a blister-like papule with burning and painful sensations, mainly on the trunk and not across the midline, so the papules of AIDS patients are diverse.