Cefixime is a third generation cephalosporin, which is an antibiotic and is mainly used clinically for infectious diseases caused by bacterial infections with very good effects. Because the structure of cefixime does not contain methiodiazole group, drinking alcohol or taking drugs containing alcohol during the treatment of this drug will not cause disulfiram-like reactions such as flushing, headache, abdominal pain and rapid heartbeat. However, from the health point of view, it is recommended to drink less alcohol to avoid endangering the health of patients. Cefixime is an antibiotic and must be used under the guidance of a doctor to avoid misuse of the drug, which is detrimental to the treatment of the patient’s disease.