Chordoma is a congenital tumor that develops in the skull base and sacrococcygeal region from the embryonic residual chordal tissue. Headache is the most common symptom. The nature of headache is persistent dull pain, often full headache, and can also extend to the occipital or cervical region. 1.Saddle chordoma: Hypopituitarism, mainly manifested as impotence, amenorrhea, body fat, etc.; optic nerve compression produces primary optic nerve atrophy, vision loss and bilateral temporal hemianopia, etc. 2.Parasellar chordoma mainly manifests as motility, talipes and abducens nerve paralysis, with abducens nerve involvement being more common. 3.Slope chordoma Slope chordoma is the most common type of skull base chordoma, specifically divided into upper, middle and lower slope chordoma, the upper slope chordoma often involves the articulating nerve, the first manifestation is weakness of one eyelid, and in severe cases, the eye cannot be opened. Mid-slope chordoma often involves the abducens nerve and the first sign is double vision. If the tumor originates distally from the nasopharyngeal wall, it often protrudes into the nasopharynx and causes nasal disinflation, pain, and purulent or bloody discharge (these patients are often first seen in the ENT department). Diagnosis: The common diagnostic tools in clinical practice are CT scan and MRI of the skull base, through which the diagnosis can be basically established. In pathology, the surface of the tumor in early stage of chordoma is lobulated or nodular, with tumor size one, incomplete envelope and grayish white or grayish red color. The tumor tissue may have residual fragmented bone or small septum interval and soft tissue calcification. In the late stage, it is easy to bleed, necrosis and cystic change, and it is common to see single lesions. Treatment: In recent years, with the advancement of surgical techniques, especially endoscopic brain technology, chordoma of the skull base can be successfully removed surgically, and most patients can be cured. After resection of chordoma, CT or MRI examination is performed as early as possible to confirm the extent of tumor resection and the presence of tumor remnants, which is an important guideline for postoperative adjuvant radiotherapy or regular follow-up.