The disease was first reported by Mayer in 1829, and later Rokitansky and others studied the disease in depth, so the syndrome was called Mayer-Rokitansky-Kuster-Hauser syndrome, with an incidence of about 1 in 5000, and at this rate about 130,000 patients exist in China. The disease is caused by the normal development of the Mullerian ducts in the early embryonic stage, but the development stops or is not synchronized in the middle stage, so that the fallopian tubes and ovaries are normal, while the uterus and vagina are absent. Because the reproductive, urinary, skeletal, cardiovascular, and digestive systems are of mesodermal origin, abnormalities of these systems are often combined. Once diagnosed, the most common question patients ask one is what caused it. Although MRKH syndrome is a congenital disease, the main cause is related to external factors such as environmental factors, viral infections, teratogenic drugs, harmful substances, and nutritional imbalances that affect embryonic development, but for each patient, there are many causes that cannot be identified. The disease mostly occurs at 6-9 weeks of embryonic life (8-11 weeks of menopause if menstruation is regular), and because the gonads from the genital ridge occur earlier, all patients have normal ovaries, and the karyotype is 46,XX. The other concern of the patients is how to treat the two demands in front of them, sexual life and fertility. Vaginoplasty solves the problem of sexual life after marriage, which is not a problem anymore, and the timing of the surgery is good, and different surgical methods can be chosen depending on the individual. Surrogacy is theoretically feasible, and there are many successful cases in practice, in which the patient gets a biologically related child, but this method involves ethics, policy, management, law and many other issues, which makes it prohibited in many countries and illegal in China. The other way is uterine transplantation, which feels far away from us, and domestic scholars also think that the cost is too great to be feasible, but there are many patients consulting, so here are some brief introductions. This study was conducted earlier in Turkey, and after 2 years of observation after successful transplantation, doctors performed in vitro fertilization embryo implantation for this patient, but ultimately did not get a successful birth. Recently doctors in Sweden have reported 9 cases of transplantation, which are still under observation. The technical difficulties involved in this treatment, the source of the donor and the high cost make it difficult to promote it clinically, and the ultimate success of the fertility is even more challenging. I answered the patient’s mother’s inquiry with no choice, and communicated with her about the physical and mental problems of her child’s growth. The sad mother did not forget to say thank you when she walked out of the clinic, really did not want to face such a child, inwardly lamented the limitations of medicine in front of the disease, with apologies wishing the little girl to grow up healthy, 5 years 10 years, but hopefully the development of medicine can fulfill the dream of this group of mothers.