Allergic diseases are diverse and can involve several systems, such as skin, respiratory, digestive and ophthalmic. Allergen detection is a prerequisite for disease treatment. The variety of allergens and the emergence of new allergens make allergen detection difficult. There is no allergen test that can ensure that all allergens in a patient are detected. According to the allergen analysis of most patients, there are some major allergens that are mainly found in the food group and the inhalation group, and therefore the prick test for these two groups remains one of the main allergen detection methods. This method involves puncture of the upper limb of the test subject, where the skin is exposed to the relevant reagent through the puncture point, and the allergy result is determined by the skin reaction after 20 minutes. Some chronic allergic reactions, such as chronic eczema, require allergen detection through patch testing. Nowadays, the more commonly used patch test in China is to stick the prepared patch reagent on the normal skin of the tested person (usually on the back or upper limbs), remove it after 48 hours, and then have the results read by professionals after another 24 hours. If red spots or even blisters appear on the contact points of which reagent, it means that the substance represented by the reagent is the allergen. Although the above two allergen testing methods are more commonly used, they both have the disadvantage that the types of tests are limited and sometimes not all allergens can be found. Currently, there is a method of allergen detection, the principle of which is to screen by biological resonance, the screening range includes more than 1,000 kinds of substances in 35 categories, and patients can bring their own suspected allergens for individual testing, which is one of the most varied methods of detection at present, but it is sometimes affected by the operator’s technical level of proficiency. Some food intolerance tests can also be performed on the patient’s serum, the results of which are also subject to uncertainty. Each method of allergen testing has advantages and disadvantages, and a combination of methods may be used if necessary at the discretion of the physician. Once the results of the allergen test are available, the patient can make changes to his or her daily life accordingly. For example, those who are allergic to a certain pollen should try to stay away from pollen, those who are allergic to a certain food should avoid eating it, and those who are allergic to a certain contact substance should try to avoid re-exposure, etc. Desensitization is a common treatment. Desensitization is a common treatment. If complete desensitization can be achieved, theoretically the disease can be completely cured. However, due to the changing condition of the patient and the changing spectrum of allergies, there are often differences in the efficacy of the treatment in some patients. Desensitization can be carried out by both the prick test method, which is carried out by subcutaneous injection of desensitizing drugs, and the bioresonance method, which is carried out by bioresonance. Either method is often combined with the use of medication, so clinical guidance from a medical professional is crucial. Nowadays, some organizations take advantage of patients’ urgency to blindly carry out allergen testing and related treatments, which not only fail to effectively treat the disease, but also complicate the condition and put the public’s health in jeopardy, so I hope we can be vigilant.