At present, the incidence of infertility in our country is on the rise, more and more people’s attention, this paper on the incidence of female infertility rise in the reasons for the overview. First, the increase in the rate of reproductive tract infections Research shows that 20~40% of female infertility is caused by infection. Pathogenic microbial infection is an important cause of infertility. At present, the incidence of reproductive tract infections in China is on the rise. 1, mycoplasma infection Mycoplasma exists in the male and female genital tract and semen specimens. Mycoplasma solani can live in symbiosis with other flora and develop into pathogenic microorganisms when the body’s immunity is low or the mucosa is damaged. Mycoplasma produces large amounts of ammonia by breaking down urea from diseased tissues. The cytotoxic effect of ammonia causes degeneration and necrosis of the mucosal cells of the genital tract and stagnation of tubal cilia movement, which interferes with the formation of a fertilized egg. Mycoplasma can also make sperm brake or death. 2, Chlamydia trachomatis Chlamydia trachomatis is a class of cell-hosted unique microorganisms. Risk factors associated with the development of Chlamydia trachomatis include age (20-40 years old), frequent change of sexual partners, new partners in the last six months, sexual partners with symptoms of genitourinary tract infections, and sexual behavior without condom use. 3, gonococcus Gonococcus is more common in young men, and gonococcal epididymo-orchitis can lead to persistent oligospermia and azoospermia. Some female gonococcal infections can cause pelvic inflammatory disease leading to infertility and ectopic pregnancy. Mycoplasma solani and Chlamydia trachomatis can cause cervicitis, endometritis, and salpingitis, and long-term chronic inflammation can lead to tubal hydrops, incomplete passage, obstruction, or immune infertility. There is also a risk of miscarriage, teratogenesis, stillbirth, and preterm labor in those infected with Mycoplasma solani. The incidence of infertility is related to the number of episodes of pelvic infection. Foreign literature reports that 21% of patients with 1 episode of pelvic infection will experience infertility, and the incidence increases as the number of episodes of pelvic infection increases. About 1/2 of the patients can not get timely and effective treatment because the symptoms are not obvious, thus the risk of infertility increases. Second, the increase in the amount of abdominal and pelvic surgery (abortion and cesarean section) Abdominal and pelvic surgery (e.g., appendicitis) on the pelvic cavity interference, increasing the chance of postoperative infection. The advent of a new era has caused a change in attitudes, however the lack of medical knowledge and taking protective measures has significantly increased the incidence of unplanned pregnancies in women. Induced abortion, especially multiple abortions, not only causes damage to the endometrium, but also bacterial infections that can lead to tubulitis, which can lead to ectopic pregnancy and infertility. Some scholars believe that cesarean section directly or indirectly affects the function of the fallopian tube, which is due to surgical injury and concurrent pelvic inflammatory adhesions. In recent years, China’s maternal caesarean section rate is much higher than that of developed countries, and the caesarean section rate in some hospitals is even as high as 80%. Third, the wide application of intrauterine devices In recent years, the application of intrauterine devices has become one of the most important birth control measures. There is a significant correlation between IUD and endometritis. At the same time, the time limit for placing the IUD is related to the occurrence of ectopic pregnancy. There is an increased risk of secondary infertility with IUD placement due to pelvic inflammatory factors.