Seeing that the second child is about to be liberalized, the post-60s and post-70s can’t help but be tempted. The last train, the absolute last train, the nagging and demands of the elderly, the jokes and exhortations of coworkers and friends, it seems that, when you reach middle age, if you don’t have a second child, you’re out. The 2014 Canadian Clinical Practice Guidelines: Anxiety, Post-Traumatic Stress and Obsessive-Compulsive Disorders mentions that the lifetime prevalence of anxiety and related disorders is as high as 31%, and that the lifetime prevalence of social anxiety disorders in women is about 8-12%, which is higher than that in men. The lifetime prevalence of Generalized Anxiety Disorder (GAD) is 6%, with peaks in late adolescence through 20 years of age and in the 30s and 40s. The pressure and distress of having children again makes most middle-aged couples anxious. Cognitive Behavioral Therapy (CBT) has been proven to be the most effective psychotherapeutic approach by Meng Fanwei, Infertility Treatment Center, Qilu Hospital, Shandong University. And both group and individual psychotherapy models are effective for panic attacks, social anxiety disorder, generalized anxiety disorder, specific phobias, obsessive-compulsive disorder and post-traumatic stress disorder. Here, middle-aged couples must recognize the fact of declining fertility, self-adjustment of the mind, reduce the impact of anxiety on women’s endocrine, and hold a normal mind, is conducive to conceiving again. I wish you an early pregnancy.