Primary nephrotic syndrome should be treated with glucocorticoids rapidly after diagnosis. The so-called standard therapy of glucocorticoids for nephrotic syndrome is divided into three main phases: (1) Initial treatment phase: In newly diagnosed cases of primary nephrotic syndrome, the dose of initial treatment phase should be large enough. In adults, the dosage of prednisone is 1 mg/kg per day and the weight is calculated according to the ideal weight, which we believe can be easily calculated by the following formula: ideal weight = [actual weight + (height – 105)]/2. In children, the dosage is 1 to 2 mg/kg per day, and the younger the age, the higher the dosage, but the daily dosage of the hormone should not exceed 70 mg. If the patient has decompensated liver function, then the patient should be treated with equal doses of prednisolone instead. Treatment. The application of hormone should be taken early in the morning after a meal around 7:00 a.m. This phase is the high-dose hormone treatment phase, and the course of treatment is 8 weeks in total. (2) Dose reduction phase: After 8 weeks of treatment with high-dose glucocorticosteroids, the dose should be reduced regardless of whether the treatment effect is good or not (in recent years, some scholars have also proposed to use high-dose hormone treatment for 12 weeks before seeing the effect, which can be referred to). The dose should be reduced by 10% of the original dose every 1 to 2 weeks, usually by 5 mg for adults, and gradually reduced to a smaller dose of 0.5 mg/kg/day for adults and 1 mg/kg/day for children, and then according to the patient’s condition: ① If the patient has achieved complete remission during the initial treatment phase, the dose should be reduced slowly, and the smaller the dose, the slower the dose should be reduced and the longer the duration of the dose should be. (2) If the patient does not improve after 8 weeks of high-dose glucocorticosteroid treatment and still has large amounts of urine protein or even worsens, the dose should be rapidly reduced or even discontinued and replaced by Chinese herbal medicine treatment. ③If only partial remission is achieved after the first treatment phase (proteinuria <3g/d or reduced by more than half compared with the original, and edema and other symptoms are reduced, the low-dose glucocorticosteroids should be maintained for 8 months or longer in the hope of achieving complete remission. If complete remission is achieved during the course of low-dose maintenance therapy, the glucocorticosteroid should be taken at the original amount for another 4 weeks after remission, and then reduced to the maintenance amount according to the slow rule. (3) Maintenance treatment phase: The glucocorticoid dosage is 0.2 mg/(kg?d) and then gradually reduced to discontinuation after a period of discretionary maintenance depending on the changes of the disease. In the case of the above ①, the treatment will be maintained for 4 months or longer, and then the dosage will be slowly reduced until discontinuation; in the case of the above ②, the dosage will still be reduced by 5 mg per week until discontinuation; in the case of the above ③, the treatment will be maintained for about 1 year, and then the dosage will be slowly reduced until discontinuation. In some patients, although complete remission is achieved at the initial treatment, but relapse within a short period of time (<6 months), or even relapse when the dosage is reduced to a certain level (i.e. hormone-dependent), hormone therapy can be reintroduced, and cytotoxic drugs can also be used in conjunction with treatment. If the hormone dose is reduced to the maintenance dose as described above, the treatment can be continued for 12 to 18 months. In conclusion, the treatment of nephrotic syndrome with glucocorticoids should emphasize: "the initial amount should be sufficient, the reduction should be slow, and the maintenance should be long". Of course, these methods of hormone use are written for doctors, and patients themselves must not decide the course or dose of hormone therapy, even if you repeatedly use hormones to treat your disease.