1. Self-perceived eye swelling, tears, foreign body sensation, visual fatigue, diplopia, and decreased visual acuity. The affected eye is staring, and transient vision is reduced. 2. The eyelids are swollen and the eye sockets disappear. Typically, the eyelids recede, the sclera is exposed between the corneal margin and the lid margin, and the upper lid falls late when the eye is turned downward. The lid fissures are enlarged and gaze is present. 3. Bulbar conjunctiva is congested, edematous and vasodilated, mostly in the outer canthus. The extraocular muscles are specifically dark red and congested at the stop end of the eye, with an exposed muscle pattern. 4. Protrusion of the eyeball. Unilateral or bilateral axial protrusion, with resistance to eye retraction. Late protrusion to the underside is more common. 5. Diplopia and extraocular muscle movement disorders. The extraocular muscles have a shuttle-shaped hypertrophy in the belly, and the tendons are usually not involved. The inferior rectus muscle is most likely to be involved, followed by the internal rectus muscle, external rectus muscle and superior rectus muscle. Eye movements are limited and diplopia occurs. However, when the extraocular muscles of both eyes are involved to a similar extent, there is no diplopia instead. 6. Superficial punctate keratopathy may occur, and in severe cases, patients in the active phase may suffer from corneal ulceration and perforation of the cornea due to incomplete lid closure. 7. Retractable strabismus can occur in patients in the stationary phase. 8. Conjunctival and corneal desiccation can occur due to reduced transient vision and the inability to distribute tears evenly on the corneal surface. 9.Increased intraocular pressure. 10.When hypertrophic extraocular muscles compress the optic nerve at the orbital apex, there will be impaired afferent pupillary response, color vision impairment, visual field defects and decreased visual acuity, and optic papillary edema. Mild ocular protrusion may also occur with compression of the optic nerve by the extraocular muscles. This severe condition may occur when more than one extraocular muscle is involved and there is limited upward and horizontal rotation of the eye. 11. There are often manifestations of hyperthyroidism, such as rapid pulse rate, hot and dry skin, diffuse enlargement of the thyroid gland, weight loss, wasting, muscle weakness, hand tremor, anterior tibial skin lesions or mucinous edema, and sometimes cardiac arrhythmia.