Indications for the ketogenic diet: 1. Refractory childhood epilepsy: for children of all ages with various seizure types with drug-refractory epilepsy. Numerous studies have shown that patients can be predicted to have refractory epilepsy if they have the following factors, including seizure type of tonicity, dystonia, spasticity, atypical disorientation; with certain epileptic syndromes, such as early myoclonic encephalopathy, Ohtahara syndrome, temporal lobe epilepsy; with specific etiologies, such as tuberous sclerosis, intracerebral vascular malformation, severe infection; with psychomotor developmental delay, neurological dysfunction.
2, Glucose transporter I deficiency: due to the inability of glucose to enter the brain, resulting in seizures, developmental delays and complex motor disorders.
3, pyruvate dehydrogenase deficiency: pyruvate cannot be metabolized or acetyl coenzyme A leads to severe developmental disorders and lactic acidosis.
Contraindications to the ketogenic diet: Those with disorders of fatty acid transport and oxidation. including carnitine deficiency and pyruvate dehydrogenase deficiency; inability to maintain adequate nutrition; having an identified surgical epilepsy lesion; lack of parental or guardian consent; and unqualified guardians are all relative contraindications to the use of this method.