Fatty liver and hepatomegaly are prone to hepatitis, liver function damage, cirrhosis and other hazards. When patients have fatty liver for a long time, due to the high fat content in the liver, fatty degeneration of hepatocytes occurs, which leads to rupture and damage of hepatocytes, affects the function of hepatocytes, and induces steatohepatitis. And hepatomegaly is mainly considered as hepatocellular injury with hydropic degeneration of hepatocytes, causing hepatomegaly. If the patient is not carefully handled, it is easy to appear the harm of hepatitis and cirrhosis due to hepatocellular injury. In the long run, it is easy to develop portal hypertension leading to ascites, upper gastrointestinal bleeding, dyspepsia and other adverse reactions. Therefore, when the patient has fatty liver and hepatomegaly, it is necessary to actively identify the cause of liver injury and deal with it accordingly to prevent serious progression of the lesion and lead to greater harm.