Xiao Li, 28 years old, has been suffering from SLE for many years. She is most distressed about how to get through the long cold winter because her fingers change color when she encounters cold environment, starting with pale, followed by purple, and accompanied by unbearable pain. She has tried many treatments, such as medication and Chinese herbal medicine, but the effect is not good and she feels frustrated. In fact, what she suffered from was Raynaud’s syndrome. Raynaud’s syndrome is not uncommon in clinical practice, it can be the main manifestation of Raynaud’s disease or a clinical manifestation of other diseases. The condition is most common in young women aged 20-30 years old, and most often develops after cold or emotional stress, mainly manifested as a sudden change in finger color to pale, followed by purple. The attack often starts at the fingertips and later extends to the entire finger or even the palm, accompanied by localized coldness, numbness, pins and needles, and decreased sensation. After a few minutes, the skin gradually turns flushed, warms up, and feels burning-like swelling and pain, and finally the skin color returns to normal. The attack can often be relieved by warming the limbs with hot drinks or alcohol. The duration of each attack can be as long as 15 to 30 minutes. In a few patients with severe cases, there are nutritional changes in the finger (toe) ends, such as deformed and brittle nails, atrophy of the batch pad, thinning of the skin, loss of wrinkles, and ulceration of the nail tip even or gangrene. Patients with less severe Raynaud’s syndrome can take a number of measures to prevent attacks, including avoiding cold stimuli and emotional stress; abstaining from smoking; avoiding ergotamine, beta-blockers and contraceptives; and changing jobs if possible for obvious occupational reasons (long-term use of vibrating tools, working at low temperatures). Relieving the patient’s mental concerns and maintaining optimism is an important measure in prevention. Currently, the main clinical treatment options include drug therapy, surgery, Chinese herbal medicine, and biofeedback therapy. Most patients can partially relieve their symptoms after the above treatments, but there are some patients like Xiao Li who do not have significant results, and local injection of botulinum toxin treatment will undoubtedly bring a blessing to these patients. Botulinum toxin treatment is a mature treatment method that has been widely carried out in the treatment of blepharospasm, facial muscle spasm, spastic squint, hyperhidrosis and many other fields, and has achieved good results. In the treatment of Raynaud’s syndrome, foreign countries have made some useful attempts since 2004, and have achieved good results in relieving pain and promoting ulcer healing, especially for some patients with refractory Raynaud’s syndrome. The Botox treatment led by Dr. Jin Lingjing, the deputy chief physician of our hospital, undoubtedly brings hope to patients with severe Raynaud’s syndrome, and we hope to relieve the pain and improve the quality of life for those patients with severe Raynaud’s syndrome through Botox treatment.