Patients with diabetes who develop neuropathy can be treated with oral methylcobalamin or epalrestat, or a combination of the two. Poor glycemic control in patients with diabetes can lead to peripheral neuritis. Methylcobalamin can play a role in clinical nerve nutrition, through the supplementation of vitamin B12 repair and nutritional nerve and improve the symptoms. Clinical oral administration of such drugs generally have no adverse reactions, occasionally can be seen gastrointestinal adverse reactions, such as dyspepsia, nausea, vomiting, etc., generally no special contraindications. Epalrestat is a glucuronide dehydrogenase inhibitor, which can reduce the effect of glucose on the nervous system. When Epalrestat is used in diabetic peripheral neuropathy, it should not be taken by patients who are allergic to this drug, which can lead to anaphylactic skin reactions, increased transaminase levels in the liver, and gastrointestinal adverse reactions. In diabetic patients with peripheral nerve inflammation, it is recommended that Epalrestat be taken in combination with methylcobalamin, which has relatively fewer side effects and facilitates recovery from peripheral neuropathy. When discomfort occurs while taking the medication, please consult a doctor promptly.