Stubborn mouth ulcers can be treated with oral or intramuscular immunity-boosting medication transfer factor. However, stubborn mouth ulcers in fixed locations require medical attention to rule out cancerous ulcers. Persistent mouth ulcers are a sign of low autoimmunity. When there is a decrease in resistance or a combination of other diseases of the organism’s system, the manifestation in the mouth is a mouth ulcer. You can take oral or intramuscular transfer factor to improve autoimmunity and slow down the frequency of ulcers. Daily diet, eat more vitamin-rich foods, such as vitamin B or vitamin C foods. Including tomatoes, oranges, grapefruit and so on. Life pay attention to the regularity of work and rest, do not eat spicy and stimulating food, do not stay up late, strengthen physical exercise to improve their own resistance. Therefore, stubborn mouth ulcers can be oral or intramuscular injection of transfer factors, while with physical exercise regular routine to improve their own immunity. If the mouth ulcers always appear in the same location and are more stubborn, we need to be alert to cancerous ulcers, and recommend that we go to the hospital in time. The above medication should be used according to the doctor’s prescription.