It is well known that ectopic pregnancy is one of the most common emergency abdominal conditions in obstetrics and gynecology and is the leading cause of maternal death in early pregnancy, with approximately 5% of pregnancy-related deaths resulting from ectopic pregnancy. Over the past decade, the incidence of ectopic pregnancy has gradually increased. So, what factors actually increase the occurrence of ectopic pregnancy? Could contraceptive failure be one of the causes? Obviously, any form of contraception will reduce the chances of pregnancy and thus the risk of ectopic pregnancy. However, once a pregnancy occurs as a result of contraceptive failure, the probability of ectopic pregnancy varies depending on the method of contraception. Short-acting oral contraceptives, IUDs, and female sterilization have been reported to increase the risk of ectopic pregnancy to varying degrees after contraceptive failure. The emergency contraceptive pill is a medication that is effective in preventing unwanted pregnancies after unprotected sex. The levonorgestrel emergency contraceptive pill (trade names: Yutin, Antin, Huiting, Bostin, Yitin, etc.) is available over-the-counter in many countries, including China, which means that it can be easily purchased from pharmacies of all sizes without a doctor’s prescription. When taken within 72 hours of unprotected sex, its effectiveness in preventing unwanted pregnancy ranges from 52% to 94%. Because of its convenience, affordability, and reliable contraceptive effect, it is rapidly becoming popular and preferred by women, even as an alternative to conventional contraceptive methods. Although, similar to other contraceptive methods, levonorgestrel reduces the risk of ectopic pregnancy as well as intrauterine pregnancy, the question of its safety, especially whether the risk of ectopic pregnancy increases, has been a major concern for the majority of users as the number of users gradually increases, but a clear answer has never been found. A clinical study has recently been conducted to answer this question. Does previous LNG-EC use increase the risk of ectopic pregnancy? What is “prior”? For women who are not pregnant, prior to the last menstrual period (the period before the last menstrual period) is considered prior, and for pregnant women (both intrauterine and ectopic), prior to the last menstrual period is considered prior. The answer is that previous use of levonorgestrel emergency contraceptive pills does not increase the risk of ectopic pregnancy. Does taking LNG-EC in the current cycle increase the risk of ectopic pregnancy? For women who are not pregnant, the cycle between the previous and the last menstrual period is the current cycle; for pregnant women (including intrauterine and ectopic pregnancies), the cycle after the last menstrual period is the current cycle. 1. The risk of ectopic pregnancy was not significantly increased by taking levonorgestrel emergency contraceptive pill in this cycle, however, once the contraception failed, the risk of ectopic pregnancy was significantly higher in those who took the pill than intrauterine pregnancy; 2. The risk of ectopic pregnancy was significantly higher in those who had unprotected sex again after taking levonorgestrel emergency contraceptive pill in this cycle, or took levonorgestrel emergency contraceptive pill again when they had sex again after taking the pill. From the above study, it is clear that levonorgestrel emergency contraceptive pills are effective in reducing unwanted pregnancy, however, the risk of ectopic pregnancy needs to be highly guarded in case of contraceptive failure. What should be noted when applying levonorgestrel emergency contraceptive pill? 1.In order to improve the contraceptive effect and prevent the occurrence of unwanted pregnancy, LNG-EC should be taken as early as possible after unprotected sex; 2.After taking levonorgestrel emergency contraceptive pill in the same cycle, we should avoid having sex again; or take a reliable contraceptive method (condom) during sex; 3.Levonorgestrel emergency contraceptive pill should not be used repeatedly in the same cycle; 4.Emergency contraceptive methods can only be used as 4. Emergency contraception can only be used as a temporary remedy after unprotected sex, but cannot be used repeatedly as a regular contraceptive method; 5. If menopause, vaginal bleeding, abdominal pain and other uncomfortable symptoms occur after using levonorgestrel emergency contraceptive pill in this cycle, you should be alert to the possibility of ectopic pregnancy and seek medical attention in time. In conclusion, the emergency contraceptive pill is a double-edged sword. While recognizing its role in reducing unwanted pregnancy, it is important to be alert to the occurrence of ectopic pregnancy after contraceptive failure. A better understanding of the relationship between levonorgestrel emergency contraceptive pill and ectopic pregnancy is beneficial to optimize the correct use of levonorgestrel emergency contraceptive pill, reduce the risk of ectopic pregnancy, and bring far-reaching benefits to the majority of women.