The common causes of cold lower limbs in diabetes are physiologic factors, lower limb vascular disease and peripheral neuropathy. Aspirin, methylcobalamin and other drugs can be used as prescribed by the doctor. 1. Physiological factors: cold and lower extremities in the lower temperature environment can lead to lower extremity blood circulation slows down, metabolism slows down, resulting in diabetic patients with cold lower extremities, you can strengthen the lower extremity warmth to improve the symptoms of cold lower extremities. 2. Lower extremity vascular lesions: diabetic patients due to long-term elevation of blood glucose can lead to lower extremity vascular stenosis, occlusion and microcirculation disorders, which leads to lower extremity ischemia symptoms, resulting in lower extremity cold. Antiplatelet aggregation and vasodilator drugs, such as aspirin and prostaglandin, can be used on the basis of glycemic drugs such as acarbose and insulin to control blood sugar. 3. Peripheral neuropathy: diabetic patients with long-term poor glycemic control are prone to complications of peripheral neuropathy, which makes the patient’s feet feel impaired and the limbs feel cold. Metformin, acarbose and other drugs should be used first to control blood sugar, based on the use of methylcobalamin, vitamin B1 and other nutritive drugs for nerve treatment. Diabetic cold lower limbs should go to the hospital in time to take timely treatment measures to prevent further progression of the disease.