Diabetic patients infected with Helicobacter pylori can be treated with triple therapy or drug quadruple therapy under the guidance of a doctor, as well as standardized glucose-lowering therapy. Triple therapy or quadruple therapy is commonly used to treat H. pylori. Triple therapy is the use of a proton pump inhibitor plus two antibiotics, proton pump inhibitors are lansoprazole, omeprazole and so on. The antibiotics are amoxicillin and furazolidone. Quadruple therapy is the use of a proton pump inhibitor plus two antibiotics plus bismuth. The bismuth agents are colloidal bismuth pectin and bismuth potassium citrate. Probiotics can also be taken appropriately during medication, which can effectively regulate the intestinal flora and is very helpful in treatment. Diet should avoid drinking alcohol and eating stimulating food. When eating out, it is recommended to use public chopsticks and spoons to avoid cross-infection. Diabetic patients also need to apply hypoglycemic drugs, such as metformin, acarbose, etc., or apply insulin for active blood sugar control treatment to keep blood sugar in a reasonable range. If a diabetic patient has H. pylori, it is recommended to consult a hospital in a timely manner and standardize the diagnosis and treatment under the guidance of a doctor.