When diabetic platelets suddenly and rapidly decrease, the cause of the disease should first be actively clarified, and then the treatment should be directed at the cause of the disease. For example, immunosuppressant, glucocorticoid therapy, etc., specific treatment is recommended to consult a doctor. When the platelets of diabetic patients suddenly drop rapidly, it is easy to lead to bleeding complications, such as petechiae and ecchymosis of the skin and mucous membranes, bleeding from the oral cavity and nasal cavity and other bleeding manifestations, which can be immediately given to the recombinant human thrombopoietin injections and other medications subcutaneous injection, in order to raise the platelet count as soon as possible. While raising platelets and actively preventing bleeding, the specific cause of the disease needs to be clarified as soon as possible. Common causes of diabetic platelet sudden and rapid decline include idiopathic thrombocytopenic purpura, acute leukemia, epidemic hemorrhagic fever and other diseases. It is recommended that the patient should consult the hematology department in time, improve the bone marrow aspiration and biopsy, antinuclear antibody spectrum, platelet autoantibody six, epidemic hemorrhagic fever virus antibody test and other related examinations to clarify the cause of the disease, and then the specialist physician will formulate an individualized treatment plan according to the patient’s condition.