Patients with advanced stage of cancer are prone to fever in the afternoon or at night, which can be caused by a variety of reasons, such as tumor, infection, drugs and long-term malnutrition. To deal with fever, the patient needs to be treated for the cause and symptomatic treatment as follows: I. Treatment for the cause If the malignant tumor is combined with infection, fever is often the earliest symptom of infection, and the most effective antibiotics should be applied according to the drug sensitivity test in a timely manner for targeted treatment. For patients who are receiving radiotherapy, blood routine should be checked regularly. When the total number of white blood cells or neutrophils are low, radiotherapy should be stopped to prevent secondary infection. Symptomatic treatment, i.e., take measures to lower the temperature, including physical cooling, medication to reduce fever. 1.Physical cooling: 25%-30% ethanol 200-300ml can be used to rub the body to the armpits, groin, popliteal fossa and other blood vessel-rich places, and the stay time should be a little longer, in order to promote heat dissipation. Or use ice, ice bag placed in the forehead, armpits, to promote heat dissipation. 2, drug antipyretic: if the body temperature is more than 38.5 ℃, can use compound aminopyrine injection intramuscular injection or anacin injection nasal drops to reduce fever. Prolonged afternoon low fever can be used as appropriate anti-inflammatory analgesic drugs slow-release, but long-term use may damage the gastric mucosa, triggering gastric hemorrhage, and at the same time easy to produce drug resistance, antipyretic effect becomes worse. In addition, you can also consider choosing Chinese medicine treatment, which is effective in reducing fever.