The recent airing of “Not to be disturbed” has caused many people to come to the hospital to consult medical knowledge about pigmented nevi and pigmented spots, among which there are many skin heterochromatosis. The so-called cutaneous heterochromatosis refers to a class of skin diseases characterized by spotty pigmentation accompanied by hypopigmented spots, classified as symmetrical pigment anomalies, pancystic pigment anomalies and diffuse pigmentation with spotty hypopigmentation. To date, the treatment of these dermatoses has been difficult, but the rapid progress of contemporary science and technology has brought physical therapy combined with oral medication to improve the symptoms of some patients, but different diseases need to be treated differently. In some difficult cases, free genetic testing is now available from our research team to identify them.