Minor triple yang, or hepatitis B minor triple yang, is usually amenable to interferon. Minor triple positive refers to patients with hepatitis B surface antigen, hepatitis B e antibody, hepatitis B core antibody positive, and e antigen negative, its virus replication is not active, but still has the possibility of infection, its liver function may still be damaged, so need to carry on the treatment, often need to inhibit the replication of hepatitis B virus drugs. Interferon can activate the antiviral protein gene, which produces antiviral protein to prevent the replication of viral nucleic acid and protein synthesis, so it can inhibit the replication of the virus, so as to achieve the purpose of antiviral. Interferon treatment can be carried out under the guidance of a doctor when the patient’s liver function test alanine aminotransferase is more than twice the normal value, the bilirubin value is less than five times the normal value, the albumin value is more than 32g/L, and the activity of prothrombin is more than 60%. The use of drugs need to follow the doctor’s instructions, not unauthorized use of drugs, discomfort, should be timely to the hospital for medical treatment.