Recently, young patients with severe painful urinary frequency have been coming to the hospital. Patients even say “I have a urinary tract infection, the doctor should give me a shot” when they arrive at the hospital. However, the test results do not match the severity of their symptoms. In fact, “frequent, urgent, painful urination” is not necessarily a urinary tract infection, there is a special kind of urinary tract pathology that occurs in patients who have been abusing ketamine for a long time. Ketamine, or ketamine, is a non-barbiturate narcotic. It has been abused in recent years as a new type of drug by some young people. It produces a certain short-term euphoria after use. However, the damage it produces is long-lasting. The symptoms of damage to the urinary tract caused by ketamine include urinary tract irritation such as frequency, urgency, painful urination, hematuria, difficulty urinating, and urge incontinence. There may be a reduction in bladder capacity or bladder contracture, with a decrease in urine volume each time; imaging tests may show hydronephrosis, ureteral dilatation, and bladder contracture. Urodynamic tests show hypersensitivity of the bladder and unstable bladder; renal insufficiency may be manifested in later stages. As for the treatment, there is no exact and effective way. Stopping or reducing the abuse of K-powder is effective in reversing the corresponding symptoms, but some of the damage is permanent. m-blockers have been shown to alleviate the symptoms of overactive bladder in some patients. Sodium pentosulfate may also be tried. Bladder instillation of sodium hyaluronate is also effective. Surgical treatment is required at a later stage.