One day in January 2013, a handsome 23-year-old man came into the urology clinic complaining about the inconvenience caused by a fleshy lump on his scrotum. Although it was only 3 cm when it was discovered 6 years ago, it had suddenly grown 1 cm in the past 6 months and was painful when rubbing against his underwear while walking, causing inconvenience to his life. During physical examination, the doctor found a flat round superfluous organism with a tip on the right wall of the scrotum, about 4X3X0.8cm3 in size, with normal skin color, smooth surface and no folds, with a tip length of about 0.5 cm and a tip diameter of about 0.3-0.5 cm. The tumor was resected as an outpatient, and the condition was cured at the follow-up examination one week later. Molluscum contagiosum (molluscum contagiosum) is a benign connective tissue tumor of the skin, soft, skin-colored, mostly with a tip, confined to the axilla, neck, and groin, and even a case of molluscum contagiosum on the palate was reported in 2010. In this case, it is very rare to find a large scrotal bulge, and it only came to the clinic when walking caused pain. But don’t think that just because it is a benign tumor, you can rest easy. It can be a cutaneous sign of a syndrome such as Gardener’s syndrome (dermatome, osteomalacia, intestinal polyposis) or (BirtHogg Dube syndrome). Several national and international studies have shown that dermatophytosis may be a skin marker of colon polyps, with a susceptibility of even 80.4%, while colon cancer is the result of malignant transformation of colon polyps, with a chance of about 5%. It is on this basis that patients with skin polyps who also have symptoms such as abdominal pain, blood in the stool and occult blood should actively undergo colonoscopy and other tests. Secondly, the high incidence of diabetes mellitus in patients with dermatomes has been noted as early as the 1970s, and most of them are non-insulin-dependent diabetes mellitus, and even some patients with presenting dermatomes do not have diabetes mellitus at the time of examination but develop it several years later. In the national literature, 5 cases of occult diabetes were found in 30 patients. In conclusion, a simple dermatome should not be underestimated, it may reflect the presence of other diseases and shows the importance of long-term follow-up of dermatome patients.