Itchy skin during recovery from acute pancreatitis may result from bilirubin irritation of the skin. Bile reflux can cause acute pancreatitis, as the pancreatic and common bile ducts converge to share a common opening in the juxtapical abdomen of the duodenum, and when stones, roundworm impaction, and bile duct inflammation are present, this may lead to obstruction of the common duct or bile reflux, which causes abnormal activation of pancreatic digestive enzymes to digest the pancreas and its surrounding organs. In this case, it may be due to the presence of biliary pancreatitis, or it may be the result of damage to the liver cells during acute pancreatitis. In the case of hepatocellular damage or cholestasis, the metabolism of bilirubin is impaired, and bilirubin is deposited in the skin to irritate the skin and produce an itchy sensation on the skin. In addition, the presence of allergies, eczema and other diseases should be clarified. Patients should seek medical attention for examination in time to avoid delaying the condition.