Can silicone oil be stored for a long time? How long after silicone oil is injected do I remove it? Silicone oil generally cannot be stored intraocularly for a long time due to its complications. There are different reports on the time to remove silicone oil, some advocate removing it as early as 4 to 6 weeks after surgery, while others advocate not removing it until there are no complications with long-term filling. A detailed fundus examination should be performed before removing the silicone oil, and laser photocoagulation should be performed if necessary. Complications increase over time with silicone oil in the eye and are related to the quality of the silicone oil, surgical technique, and individual patient factors. For some patients with one eye, those who are fearful of reoperation due to multiple surgeries, or for some other reason who do not wish to have another surgery, appropriate delay of silicone oil removal or temporary silicone oil filling may be considered. The decision to remove silicone oil should not only emphasize the timing, but also the incidence of complications and the trade-offs, especially when silicone oil is used in very severe cases of retinal detachment. Management of complications during silicone oil removal will help maintain retinal repositioning and improve visual function.