In the face of various radiation therapy methods how to choose sometimes there are many different opinions, as a patient how to choose, in fact, I think from a doctor’s point of view the main thing to grasp the three principles, first is the best efficacy, followed by the lightest damage, but also refer to the patient’s situation including the condition and economic situation, damage has become a current problem worthy of attention. At the same time, we need to understand the characteristics of each treatment method, there is no one-size-fits-all method, sometimes need several methods of integrated treatment. γ-knife three-dimensional dose focus more concentrated, the surrounding normal tissue irradiation less, high mechanical accuracy, small error, one-time completion, more suitable for smaller lesions, especially intracranial benign and functional lesions. x-knife on the gas pedal implementation, can be a machine multi-purpose, reduce hospital expenditure, but the dose focus and accuracy is not as good as the γ-knife. However, the dose focus and precision are not as good as γ-knife, which can be divided into treatment sessions and is more suitable for larger malignant lesions. No matter head or body when the lesion is in early stage, small and regular, γ-knife treatment can be preferred, especially for intracranial, lung, liver and other parenchymal organs with multiple metastases, γ-knife treatment is preferred. When the tumor is in advanced stage, the invasion range is large, irregular shape, located near the digestive tract and radiation sensitive organs should be preferred to 3D conformal radiotherapy. Of course, under the premise of considering the efficacy and complications, for patients with good economic conditions, some tumors can also choose radio-wave knife or proton radiotherapy, in short, individualized and comprehensive treatment is the development direction of future radiotherapy.