It is also called congenital ovarian hypoplasia syndrome. It is caused by the lack of an x chromosome in the child and is seen in girls. The incidence is about 1 in 10,000 newborns. They generally show delayed growth, dense hair, low posterior hairline, wide breast spacing, barrel chest, and some may have mental retardation or congenital malformations of varying degrees, such as congenital heart disease, kidney malformations, and skeletal malformations. Children are prone to idiopathic hypertension, diabetes mellitus, and thyroid disease, etc. Children with less severe disease often exhibit growth retardation. The absence of secondary sexual characteristics at the age of puberty (12 to 13 years): poorly developed ovaries, young female external genital organs, no mammary gland development, no menstruation, etc., attracts the attention of parents and leads to hospital visits. The diagnosis can be clarified by performing chromosome examination. The main treatment is to solve the problem of short stature of the child, which can be treated with growth hormone and estrogen starting at the age of 13~15, which can promote the development of secondary sexual characteristics and improve the psychological state.