Chronic constipation may cause increased risk of colorectal cancer

 A study presented at the annual meeting of the American Gastroenterological Association showed that patients with chronic constipation have an increased risk of developing other benign tumors of the intestinal tract at the colorectal cancer level. Constipation is a common gastrointestinal discomfort that occurs when the water absorption of the large intestine is hyperactive or the contraction of the intestinal muscles is slowed or retarded, causing stool to pass through the large intestine too slowly and the stool to become hard and dry. Patients with chronic constipation have fewer bowel movements, less than three per week, and are often associated with difficulty in passing stool. The reported study compared 28,854 patients with chronic constipation with 86,562 patients without constipation, and the study medical records were obtained from a database from January 1999-September 2011. The results of the study found that patients with chronic constipation had increased rates of colorectal cancer and benign intestinal tumors compared to patients without constipation. The risk of colorectal cancer and benign intestinal tumors was 1.78 and 2.70 times higher in patients with chronic constipation than in healthy individuals. The possible reasons for this result are the prolonged passage of stool through the colon and the increased contact time of the colonic mucosa with carcinogens that accumulate in the intestinal lumen. Chronic constipation may cause an increased risk of colorectal cancer, and studies have shown that it may play an important role in the development of hepatic encephalopathy, breast disease, and Alzheimer’s disease, and excessive forceful bowel movements may even trigger acute cardiovascular accidents. Therefore, chronic constipation should also be noted.