The following six aspects should be reminded to avoid failure: 1. Failure of ovulation promotion First of all, the reasons for failure of ovulation promotion. Ovulation promotion refers to the use of drugs to promote a woman to ovulate more eggs at one time, while normal women only ovulate one egg per menstrual cycle. Generally, in older women, the ovarian reserve is no longer available, that is to say, the number of follicles in the ovarian reserve is very small, and the remaining ones are almost not of good quality. Some women with premature ovarian failure have low innate reserve and are also prone to failure. In addition, women with polycystic ovary syndrome have difficulties in ovulation promotion due to abnormal follicle development, and are prone to ovarian hyperstimulation and sometimes have a low success rate. For women who are healthy and have a good ovarian reserve, failure of ovulation induction may also occur when the timing of ovulation induction is not good, or when they happen to be sick, over-stressed or fatigued during ovulation induction. Of course, we do not rule out the possibility of failure due to inappropriate dosage of medication or incomplete IVF protocols by doctors, resulting in failure of ovulation promotion without personalized protocols. 2. Failure of egg retrieval Failure of egg retrieval means that the woman has a certain number of follicles after ovulation, but the oocytes in the follicles are not successfully extracted. The chance of this is very low, about 1 in 1000. When the number of follicles is low, the chances of failed egg retrieval occurring are relatively high. However, if the number of follicles is sufficient, it is rare that the eggs are not retrieved and the technology for this procedure is relatively mature. There is a “empty follicle syndrome” that can lead to failed egg retrieval. The incidence is about 0.5%. The cause of empty follicle syndrome is unknown and may occur repeatedly in some unfortunate patients. 3. Failure to form a fertilized egg After the egg is removed, the egg has to unite with the male sperm to form a fertilized egg. Failure in this process is related to the quality of the eggs and sperm, which cannot be easily predicted beforehand. If no attention is paid to higher preconception and improving the quality of the eggs and sperm beforehand, the embryos may be of low grade and difficult to be implanted after transfer. Couples who generally fail in this segment often have been investigating for many years and many programs and cannot find the specific cause of their infertility. This means that the reason for their inability to conceive is most likely due to the poor quality of the eggs or sperm, having chromosomal problems is common, and even more so for those who are older. Therefore, couples who are preparing to get pregnant should pay attention to their health, raise their sperm and eggs well, and pay attention to avoid some unfavorable factors in their daily life (for more details, please refer to my other articles) 4. Failure to form embryos The fertilized egg will develop to form an embryo, and the qualified embryo will be transferred into the mother’s body. This process depends on the quality of the fertilized egg. If the fertilized egg is not good, or if the quality of the embryo formed is not good, it will lead to failure and the transfer will not be possible. 5.Failure of implantation In addition to the quality of embryos, there is also the endometrial environment of women. If the endometrium is too thick causing hyperplasia and inflammation, the bad environment will have a great impact on conception, and too thin will also affect the final implantation. 6, pregnancy failure After the embryo is transferred to the mother, we have to wait for the mother to get pregnant. The failure rate of this this link is relatively high, on average about 60% of women will show failure in this link (i.e. after IVF-ET treatment, on average only 40% of cases are successful in pregnancy). Younger women are slightly better, with a failure rate of about 40%, and older women may reach 70-80%. Especially for women after the age of 40, 80-90% will fail and the chances of a successful pregnancy may be only about 10%.