The results of a U.S. study (published online Feb. 4, 2014, in JAMA InternMed) that included more than 380,000 subjects (with a mean follow-up period of 12 years) suggest that Internal Medicine) that included more than 380,000 subjects (with a mean follow-up period of 12 years) showed that supplemental active calcium intake of more than 1,000 mg/d was associated with an elevated risk of cardiovascular disease (CVD) death in men compared with non-supplemented individuals; however, there was no correlation between supplemental active calcium intake and cardiovascular death, heart disease death, and cerebrovascular disease death in women. deaths, heart disease deaths, and cerebrovascular disease deaths in women. Dietary calcium intake was not associated with CVD deaths in either men or women. Another study from Sweden of 61,433 women (median follow-up 19 years) showed that calcium intake >1400 mg/d was associated with higher all-cause, CVD, and ischemic heart disease mortality but not stroke mortality, compared with calcium intake of 600–1000 mg/d. Unrelated. Taking calcium tablets (500 mg calcium/tablet) was not associated with all-cause and cause-specific mortality, but there was an increase in all-cause mortality when accompanied by dietary calcium intake >1400 mg/d. The research paper was published February 13, 2014 in the British Medical Journal (BMJ).