Sealing therapy is a common treatment method in orthopedics, especially for the treatment of chronic sterile inflammatory diseases with good therapeutic effect, but also has the characteristics of simple and inexpensive. The so-called closed, is the direct injection of drugs in the lesion local, the local lesion to play a more direct anti-inflammatory and pain relief effect than taking drugs. As a result of the closure of some adverse reactions, making the patient a little bit about the closure of the change, when the condition requires closed treatment, very resistant to this treatment method, worried about its side effects. So, closure is really that terrible? Closure commonly used drugs are mainly tretinoin (long-acting hormone) and lidocaine (local anesthetic), tretinoin local injection has a strong anti-inflammatory effect, can quickly eliminate local inflammation, the effect is long-lasting; and lidocaine is mainly to relieve, reduce the local irritation and pain of drugs. Any drug is produced for the treatment of diseases, but invariably there will be some side effects, and closed treatment drugs are no exception. As tretinoin belongs to a glucocorticoid drug, although it has a strong anti-inflammatory effect, but if long-term, large doses, not standardized use, closed may appear after the local skin pigmentation changes, subcutaneous fat thinning and other side effects, but also cause the tendon fragile easy to rupture, if it is injected into the nerve or blood vessels will also have serious adverse consequences. Recognize the side effects of the drug is also to better avoid the occurrence of adverse reactions. If you can strictly grasp the indications for closure, personalized medication, a reasonable amount of medication, eliminate long-term multiple closure, master the correct method of operation, you can still avoid the adverse reactions and get good results.