Whether the new crown vaccine can be given for toothache needs to be judged according to the specific condition of the patient’s toothache. If the toothache is mild, there is only some irritation pain, there is no fever, etc., and the patient has not taken any medication for toothache recently, the new crown vaccine can be given. New crown vaccination is contraindicated for patients who are suffering from fever or acute illness, acute exacerbation of chronic diseases, or serious chronic diseases that are not under control. Therefore, if a patient has pain in the tooth caused by acute periodontitis, acute periapical infection, pericoronitis of wisdom teeth, or pulpitis, and has inflammation of the surrounding tissues, purulent infection, etc., or even a fever, the new crown vaccine cannot be given. Also, if a patient is taking oral anti-inflammatory drugs to relieve the symptoms of toothache, the new crown vaccine is not recommended. When a patient has a toothache, it is best to go to the hospital for relevant anti-inflammatory and pain-relieving treatment first, and then proceed with the vaccination after the symptoms have disappeared and the medication has been stopped for a week. It is important to pay attention to oral hygiene and early detection and treatment of some dental diseases to avoid aggravation of the disease due to delay.