Clinical diagnosis of vitiligo is generally not difficult based on the characteristics of the lesions, the prevalent site, changes in the condition, and family history, but should still be distinguished from common skin diseases with hypopigmentation to avoid unnecessary worries. (1) Anemic nevus: This is a kind of limited cutaneous vascular dysfunction disease, which manifests as local hypopigmentation of the skin. They are round, oval or irregular in shape and vary in size. It is usually solitary, but can also be multiple. There are no conscious symptoms. Differentiation method: rubbing the pale spots and the surrounding normal skin, the pale spots do not change, while the surrounding normal skin is congested and becomes red, making the boundaries of the pale spots more clear. (2) Non-pigmented nevus: It is a kind of congenital local hypopigmented skin disease whose etiology is still unclear. Hypopigmented nevus appears at birth or soon after birth as grayish or pale spots or patches with clear boundaries, generally round or strip-shaped, without deepening of pigment around. It is usually solitary, mostly seen on the trunk, without any conscious symptoms, and the fluorescent white spots cannot be seen by WOOD lamp examination. (3) Idiopathic punctate hypopigmentation: It is more common in the elderly, with a natural prevalence of 47% or more, and the prevalence of the population increases with age. The lesions are mostly round or oval creamy white spots less than 5 mm in diameter. The white spots have clear boundaries, no pigmentation around them, and a smooth or slightly depressed surface. The lesions are usually found on the trunk and extremities, with no conscious symptoms and no systemic damage. (4) Punctate leukoplakia: It may be a kind of hypopigmented skin disease caused by phototoxic reaction damage, mostly occurs after strong sunlight exposure, the lesions are mainly seen on the exposed parts of the limbs, hands and feet back, but also on the face, trunk, etc., the diameter does not exceed 2mm, the boundary is clear, the surface is smooth, and the number is generally more. No self-conscious symptoms, not accompanied by systemic damage. (5) pityriasis: is superficial skin disease caused by fungal infection, lesions can appear round or oval, clear boundary, size varying pale white spot, smooth surface, covered with a small amount of furfuraceous scales, mostly seen in the back, upper arm flexure side, neck and face. No self-symptomatic or with mild pruritus. Positive fungal examination, more frequent in summer and autumn, can subside in winter. (6) simple furfuraceous rash: is a kind of chronic scaly skin disease of unclear etiology, mostly seen in children, good in the face, also can occur in the neck, trunk, back and extremities. The lesion is not very clear boundary size varying light brown or creamy white spot, the surface has chaff-like fine scales, generally no conscious symptoms, occasionally have slight itching. The fungal examination is negative, and the fluorescent white spots are not visible by WOOD lamp examination. After several months or years, the lesions can fade on their own, and generally do not need to use drugs, appropriate skin care can be.