Atrial fibrillation leading to thrombosis should be given anticoagulation therapy to prevent the occurrence of arterial embolism. Patients with atrial fibrillation are often accompanied by an increase in the size of the left atrium, which will lead to local blood flow is not smooth, easy to form intra-atrial thrombus. Once a thrombus is dislodged, an arterial embolism can easily occur, which can lead to cerebral embolism, myocardial infarction, etc., and some patients may even be life-threatening. Patients with atrial thrombus should be given anticoagulant medication in a timely manner. Commonly used medications include warfarin, rivaroxaban, and dabigatran, etc. The medication can control the formation of thrombus and gradually dissolve the thrombus, reducing the risk of arterial embolism. Patients with atrial fibrillation who have atrial thrombus should go to the hospital in time and choose the appropriate anticoagulation treatment program under the guidance of physicians, but patients should be informed of the risk of arterial embolism at any time.