Cough aggravated at night with yellow sputum, often combined with bacterial infection, clinically common in pneumonia, bronchiectasis, lung abscess and other conditions. Penicillins, cephalosporins, anti-anaerobic drugs, quinolones and drugs that reduce phlegm and relieve cough are commonly used in clinical treatment. 1. Penicillin drugs: the symptoms of cough aggravated at night with yellow sputum may be related to the gram-positive bacterial infections such as Staphylococcus aureus infection, resulting in pneumonia, lung abscess and other diseases. You can apply amoxicillin capsules or penicillin V potassium tablets and other penicillin drugs under the guidance of the doctor, or you can use penicillin sodium intravenous infusion treatment. 2. Cephalosporins: Pneumonia or lung abscess, bronchial dilatation patients, sleep at night when the body’s resistance to decline, pathogenic infections lead to aggravation of the symptoms, the emergence of sleep coughing yellow sputum symptoms, you can follow the doctor’s instructions to apply a broader antimicrobial spectrum of cefixime or cefuroxime and other drugs orally, but also can be intravenous infusion ceftriaxone sodium. 3. Anti-anaerobic drugs: If the patient with inhalation lung abscess is combined with anaerobic infection, resulting in worsening cough with yellow sputum at night, the patient can apply metronidazole, tinidazole and other drugs. Metronidazole, tinidazole and other anti-anaerobic drugs can be applied. 4. Quinolones: patients with lung abscess or bronchiectasis, who have symptoms of worsening cough with yellow sputum at night, can also apply levofloxacin and other quinolones. 5. Cough and phlegm medicines: If you have cough and yellow phlegm at night, you can apply acetylcysteine, aminoglutethimide hydrochloride or bromhexine hydrochloride and other medicines that have the effect of reducing phlegm and relieving cough. If the symptoms of cough and phlegm at night are serious, you should go to the hospital in time for examination, and follow the doctor’s instructions for medication.