Objective To study the relationship between allergic status and the diagnosis and treatment of renal disease in children with nephrotic syndrome in order to improve the efficacy and prognosis. 13ug/L), came to the hospital for review in 3 months, recorded the clinical manifestations of various allergic diseases in the allergic process, recorded hematuria, proteinuria, renal function and other concomitant diseases, and discussed and analyzed the relationship between them and the influence on the diagnosis and treatment of nephropathy. Results A total of 292 cases were enrolled in this group, including 162 cases of primary nephropathy simplex, 96 cases of nephritis, and 34 cases of proteinuria at the nephropathy level. In some cases of nephroporation . , 22 cases were diagnosed as IgAN after renal penetration, 6 cases of FSGS. 4 cases of IgMN, 1 case of MPGN, 1 case of MN1 after renal failure, and 6 cases of focal hyperplasia. A total of 99 cases with IgE>200KU/L accounted for 34%, of which 47 cases with IgE>200-1000KU/L accounted for 16%, 30 cases with IgE>1000-3000KU/L accounted for 10%, 12 cases with IgE>3000-5000KU/L accounted for 4%, and 17 cases with IgE>5000KU/L accounted for 6%. In this group, there were 18 cases of hormone sensitive frequent or infrequent relapses, 18 cases with transient rash and papular eruption, 18 cases with IgE>5000KU/L, all of them showed frequent relapses, 3 of them were converted to SRNS and renal penetration to FSGS. 1 case with pollen allergy. 67 cases with ECP>20ug/L, accounting for 23%, including 25 cases with ECP>50ug/L, accounting for 9%, The highest ECP>200ug/L was found in 1 case. There were 12 cases with rhinitis and sinusitis, 6 cases with asthma, 8 cases with recurrent oral ulcers and simple vesicular infection, and 16 cases with tuberculosis infection or TB-IGM positive. There were also cases of eczema at an early age and recurrent respiratory infections during the course of the disease that were not counted. Conclusions (1) Most children with primary nephrotic syndrome have allergies, and 34% and 23% may have elevated blood IgE and ECP. (2) Elevated blood allergic indexes IgE and ECP are important factors for frequent relapse in children with primary hormone-sensitive nephrotic syndrome. (3) Long-term hyper-IgE and ECPemia can clinically transform from hormone-sensitive to SRNS and can contribute to pathological transformation: from CNS to FSGS type, and from MsPGN or focal hyperplasia to focal sclerosis or hyperplastic sclerosis. (4) For the treatment of primary nephrotic syndrome combined with allergy or stimulated with allergic status, it is important to enhance immunosuppressive therapy, improve allergic status and control triggering factors based on national evidence-based guidelines to facilitate the reduction of frequent recurrence, improve the efficacy and prognosis.