There are some patients who find in their urine test results that they have two plus signs of urine protein, but the exact cause of it is not very clear and they worry whether they are suffering from some disease. Generally speaking the factors that affect it are mainly physiological, pathological and other factors. 1, physiological factors. In the medical clinical above does not mean that the urine protein two plus is suffering from kidney disease, need to do further kidney examination, under normal circumstances healthy people will also contain a small amount of protein in the urine, usually within 20mg / h, strenuous exercise and other circumstances will be higher. 2.Pathological factors. If the patient has kidney disease and certain damage has occurred to the kidneys, this will cause the patient to discharge urine containing protein. This situation requires patients to undergo long-term treatment to get relief, and only by repairing the kidney membrane can the protein index be suppressed. 3.Other factors. If the body metabolism is disordered, resulting in flocculation of body functions, such as cold and fever, this may lead to the appearance of two plus signs. The factors of two plus signs in urine protein are mainly the above three aspects, if you find that the test results are not correct, you must ask your doctor in time, do not miss the time of treatment.