It is not recommended to administer the new crown vaccine 12 hours after drinking because it generally takes 24-72 hours for alcohol to be completely metabolized, and alcohol in the body is not completely metabolized after 12 hours, so vaccination with the new crown vaccine at this time may induce allergic reactions or aggravate adverse reactions and affect the vaccination effect. If vaccination is given after 12 hours of alcohol consumption, the following conditions may occur: 1. Local manifestations: Because alcohol can promote blood circulation, dilate blood vessels, increase the permeability of blood vessels, and increase the adverse reactions at the local injection site. The manifestations are redness, swelling, oozing, hard nodules, pain, itching, etc.; 2. Systemic symptoms: It can increase the adverse reactions of the whole body, with more serious fever, headache, dizziness, weakness, sleepiness, etc. In addition, alcohol can trigger abdominal pain, diarrhea, nausea, vomiting and other gastrointestinal symptoms. Alcohol irritates the mucous membrane of the gastrointestinal tract and can also cause gastrointestinal dysfunction. Similar side effects can occur with the New Crown vaccine itself, making it easy to confuse post-drinking reactions with side effects of the vaccine. It is generally recommended to wait 3 days or 1 week after drinking before administering the New Crown vaccine to avoid serious physical discomfort. It is important to observe the vaccine for 30 minutes after vaccination and to respond to the doctor promptly if there are uncomfortable symptoms in order to avoid serious adverse reactions such as shock.