Sleeping in the middle of the night feeling tightness in the chest, shortness of breath, want to vomit, mainly pay attention to the following conditions: 1, coronary heart disease, myocardial ischemic attack. The most common is coronary spasm, the patient may have a previous history of smoking or atherosclerosis, causing vascular endothelial dysfunction, resulting in vascular spasm lumen narrowing, causing myocardial ischemia. Examination of ambulatory electrocardiogram and coronary angiography can help to clarify the diagnosis.2. Asthma. Mostly attacked at night and early morning, due to the ventilation function is affected, patients can also appear chest tightness, shortness of breath and other related symptoms, examination of pulmonary function can help clarify the diagnosis.3, psychosomatic factors. Patients are often nervous, anxious, stressful, often accompanied by poor sleep at night, routine cardiopulmonary examination and are normal, pay attention to change the work and rest routine, regular exercise helps to relieve.