Avanafil cannot treat premature ejaculation. Since Avanafil is mainly indicated for patients with erectile dysfunction, Avanafil cannot treat premature ejaculation, and drugs for premature ejaculation mainly include selective 5 hydroxytryptamine reuptake inhibitors, such as dapoxetine, paroxetine and so on. Headache, flushing, bronchitis, rash, insomnia, high blood pressure and other adverse reactions may occur after the use of Avanafil. It needs to be contraindicated in people who are allergic to the product, patients who are taking nitrates, women, and people under 18 years of age. It should be noted that people with cardiovascular disease need to use it with caution, mainly because sexual activity can increase the risk of cardiovascular disease. Medical attention is required if the erection lasts more than 4 hours, whether it is accompanied by pain or not. Patients are advised to use Avanafil under the supervision of a doctor and not privately.