Malignant obstructive jaundice caused by pancreatic cancer, cholangiocarcinoma, gallbladder cancer, hepatocellular carcinoma and metastatic tumors in the hilar region is one of the common clinical conditions. Such patients cannot be operated immediately or at all because of severe jaundice and liver function impairment caused by biliary obstruction, and percutaneous hepatic puncture biliary drainage is appropriate in such cases. In patients with biliary obstruction with severe jaundice and hepatic impairment, decompression and drainage first can relieve jaundice and improve liver function, giving the patient the opportunity to have elective surgery again. For patients with biliary obstruction who cannot be operated, bile duct decompression and drainage can be combined with transarterial cannulation chemotherapy. Half a month to one month after the placement and drainage, Seldinger technique is used for hepatic artery cannulation, and chemotherapeutic drugs such as 5-FU, cisplatin and mitomycin are instilled via the catheter combination, which can be instilled once a month for 3-4 times as a course of treatment, which can not only relieve the patient’s jaundice symptoms, but also prolong the survival period, which is an effective treatment for malignant obstructive jaundice.