Numbness in the hands while sleeping is mostly considered to be caused by peripheral blood circulation disorders. It is usually seen in patients with atherosclerosis, who may have hyperlipidemia and diabetes mellitus, and is usually seen in middle-aged and elderly people, and can be treated with oral Ginkgo biloba drops and Peiyuan Tongbao capsule to improve blood circulation, and if necessary, oral aspirin anti-platelet aggregation treatment. If the patient has severe hand numbness, he can also apply nerve-nourishing drugs. Clinically, B-group vitamins are generally used, such as adenosine cobalamin and methylcobalamin, and vitamin B1 and vitamin B2 can also be taken orally. If the patient has diabetes, hypertension and hyperlipidemia, it should be actively given to regulate. Patients with hypertension are generally given oral irbesartan and amlodipine, and patients with diabetes are generally preferred to take metformin orally. If there is a history of hyperlipidemia generally oral statins, commonly used are simvastatin and atorvastatin. If the patient’s symptoms are persistent, they may also be caused by cerebrovascular disease, mainly seen in lesions of the brain, including cerebral hemorrhage and cerebral infarction, and promptly hospitalized for treatment after the onset.