Endometrial polyps and infertility

  The incidence of endometrial polyps is higher in women with infertility, and the rate of pregnancy increases after removal of polyps. Causes of infertility due to endometrial polyps include: (1) Endometrial polyps act as foreign bodies in the uterine cavity, preventing contact between the fertilized egg and the endometrium.  (2) Endometrial polyps can affect the local blood supply to the endometrium, preventing the fertilized egg from being laid and developing.  (3) If the endometrial polyp is located at the horn of the uterus, it may mechanically obstruct the opening of the fallopian tube and interfere with the entry of the fertilized egg into the uterine cavity.  (4) Endometrial polyps can cause irregular endometrial bleeding when the endometrium has an inflammatory response and the intrauterine environment is altered, which is not conducive to sperm survival.  (5) In patients with endometrial polyps, the endometrial sex hormone receptors are expressed abnormally, and the endometrium covering the surface of endometrial polyps responds poorly to sex hormones, which can prevent placental metaphase development.  (6) Patients with endometrial polyps often have endocrine disorders such as luteal insufficiency, abnormal ovulation, non-ovulation or high estrogen levels.