Cirrhosis often leads to death due to complications. Upper gastrointestinal bleeding is the most common complication of cirrhosis, while hepatic encephalopathy is the most common cause of death in cirrhosis. Hepatic encephalopathy, infected hepatitis, primary hepatocellular carcinoma, hepatorenal syndrome, portal vein thrombosis, respiratory injury, and peritoneal effusion. Prognosis is related to etiology, degree of liver function compensation and complications. For cirrhosis caused by alcoholic cirrhosis, biliary cirrhosis and hepatic stasis, if the cause can be eliminated before the cirrhosis progresses to the decompensated stage, the lesion can be quiescent, which is better than viral hepatitis cirrhosis and cryptogenic cirrhosis. Child-Pugh classification is closely related to the prognosis, with grade A being the best and grade C the worst. The causes of death are often complications such as hepatic encephalopathy, hepatorenal syndrome, and ruptured esophago-gastric variceal bleeding. The development of liver transplantation has significantly improved the prognosis of patients with liver cirrhosis. Prevention 1, the disease should first pay attention to the prevention and treatment of viral hepatitis. 2, early detection and isolation of patients to give active treatment. 3, pay attention to diet, reasonable nutrition, moderate alcohol consumption, strengthen labor health care, avoid various chronic chemical poisoning is also a positive measure of prevention. For those who have the above causes and are suspected of having cirrhosis, a comprehensive physical examination and relevant laboratory tests should be conducted in a timely manner, in order to obtain reasonable and active treatment in the compensated stage and prevent the development of decompensation. Regular physical examination, along with avoidance of various causative factors, prevention and treatment of possible complications.