Taking methylcobalamin for sciatica is useful. Methylcobalamin is an endogenous coenzyme B12, which can promote the synthesis of lecithin and the formation of neuronal myelin sheath, and is mainly applied to peripheral neuropathy, such as sciatica, bone spurs, herniated discs, lumbago, shoulder and neck pain. Methylcobalamin has a facilitating effect on neuronal synaptic transmission and on the recovery of neurotransmitter reduction, which can play a role in nourishing the nerves and protecting the function of the nervous system. Sciatica is caused by prolonged nerve compression, resulting in local circulation disorders and nerve damage, so the above effects of methylcobalamin have a role in its treatment. Methylcobalamin has adverse reactions, it is recommended to use the drug under the guidance of a doctor, not blindly self-medication to avoid adverse reactions.