Generally speaking, indomethacin suppositories can be used for patients with mild external hemorrhoids, but they are not recommended for patients with severe ones. In the clinic, indomethacin suppository is a kind of anti-inflammatory, analgesic effect of drugs, generally for the treatment of hemorrhoids does not have much effect. If you are a patient with external hemorrhoids and need to use indomethacin suppositories because of other medical conditions, it is recommended that patients with mild hemorrhoidal symptoms can use them, while patients with severe external hemorrhoids are not recommended to apply them. For patients with external hemorrhoids who have severe symptoms such as blood in the stool and anal pain, it is not recommended to use indomethacin suppositories because it may aggravate the patient’s condition. In this case, it is recommended to switch to an oral class of anti-inflammatory and analgesic drugs, such as non-steroidal anti-inflammatory drugs (e.g., ibuprofen), under the guidance of a doctor. The adverse reactions of indomethacin suppositories include gastrointestinal reactions (e.g., dyspepsia), neurological reactions (e.g., headache, dizziness), renal damage (e.g., renal insufficiency) hematopoietic system inhibition and so on. Its contraindications are indomethacin suppository allergy, aspirin allergy, lactating and pregnant women, children under 14 years of age, treatment of pain in the perioperative period of coronary artery bypass graft surgery. People suffering from external hemorrhoids are advised to visit the hospital for early treatment.